卢思瑶(博士，教授)
通讯地址：中国江苏省徐州市和平路57号
江苏师范大学语言科学与艺术学院
邮政编码：221009
电子邮件：lusiyao9014@outlook.com
l 个人简历及研究兴趣：
清华大学生命科学学院，博士研究生
湖南师范大学，本科
研究兴趣：基于人源诱导多功能干细胞和类脑器官模型从遗传学和分子学角度研究神经疾病相关涉及到的神经环路与发病机理。
l 研究方向：神经生物学
l 发表论文：
1. Si-Yao Lu, Chong-Lei Fu, Liang Liang, Bo Yang, Wei Shen, Qiu-Wen Wang, Yun Chen, Yan-Fen Chen, Yao-Nan Liu, Lin Zhu, Jieqing Zhao, Wei Shi, Shuangli Mi, Jun Yao. (2021). “miR-218-2 regulates cognitive functions in the hippocampus through complement component 3-dependent modulation of synaptic vesicle release.” Proceedings of the National Academy of Sciences of the United StatesofAmerica118(14).
2. Qiu-WenWang*,Si-YaoLu*,Yao-NanLiu*,YunChen,HuiWei,WeiShen,Yan-
FenChen, Chong-LeiFu, Ying-HanWang, AnbangDai, XuanHuan, FredH. Gage, Qi Xu, and Jun Yao. (2020) “Synaptotagmin-7 deficiency induces mania-like behavioral abnormalities through attenuating GluN2B activity.” Proceedings of the National Academy of Sciences of the United States of America 117(49): 31438-31447.
3. Wang, Q.W.*, Wang, Y.H., Wang, B., Chen, Y., Lu, S.Y., and Yao, J. (2021). “Synaptotagmin-7-mediated activation of spontaneous NMDAR currents is disrupted in bipolar disorder susceptibility variants.” PLoS biology 19, e3001323
4. Shen, W. *, Q. W. Wang*, Y. N. Liu*, M. C. Marchetto, S. Linker, S. Y. Lu, Y. Chen, C. Liu, C. Guo, Z. Xing, W. Shi, F. H. Gage, J. Yao, et al. (2020). Synaptotagmin7 is a key factor for bipolar-like behavioral abnormalities in mice. Proceedings of the National Academy of Sciences of the United States of America 117(8): 4392-4399.
5. Song, M., X. Yang, X. Ren, L. Maliskova, B. Li, I. R. Jones, C. Wang, F. Jacob,K.
Wu, M. Traglia, T. W. Tam, K. Jamieson, S. Y. Lu, G. L. Ming, Y. Li, J. Yao, L. A. Weiss,J.R.Dixon,L.M.Judge,B.R.Conklin,H.Song,L.GanandY.Shen(2019). Mappingcis-regulatorychromatincontactsinneuralcellslinksneuropsychiatricdisorder risk variants to target genes. Nature Genetics 51(8): 1252-1262.
6. Zheng, Y. *, W. Shen*, J. Zhang, B. Yang, Y. N. Liu, H. Qi, X. Yu, S. Y. Lu,Y. Chen,Y. Z. Xu, Y. Li, F. H. Gage, S. Mi and J. Yao (2018). CRISPR interference-based specific and efficient gene inactivation in the brain. Nature Neuroscience 21(3): 447-454.
7. Liu, Y. N. *, S. Y. Lu* and J. Yao (2017). Application of induced pluripotentstem
cells to understand neurobiological basis of bipolar disorder and schizophrenia. Psychiatry and Clinical Neuroscience 71(9): 579-599.
8. Bo., Y., Z. Yi., L. Si-Yao. and Y. Jun. (2017). Electrophysiological Study of Synaptotagmin Ⅰ Deletion Using CRISPR/Cas9. Progress in Biochemistry andBiophysics44(6): 515-522.)